Table 4 Risk factors for mortality in fluconazole resistant C. parapsilosis
Survive (n = 69) | Death (n = 19) | p value | |
|---|---|---|---|
Demographic features | |||
Age years, median (IQR) | 62.00 (1–- 91) | 64.00 (1–- 80) | 0.883 |
Sex male, n (%) | 38 (55.1%) | 12 (63.2%) | 0.607 |
Patients’ underlying diseases | |||
Diabetes Mellitus, n (%) | 7 (10.1%) | 3 (15.8%) | 0.445 |
Hypertension, n (%) | 3 (4.3%) | 3 (15.7%) | 0.294 |
Hematological malignancy, n (%) | 11 (15.9%) | 6 (31.6%) | 0.186 |
Solid organ malignancy, n (%) | 6 (8.7%) | 3 (15.8%) | 0.399 |
GI malignancy, n (%) | 33 (47.8%) | 9 (47.4%) | 1.000 |
GI Diseases, n (%) | 16 (23.2%) | 7 (36.8%) | 0.249 |
Hepatobiliary system diseases, n (%) | 7 (10.1%) | 0 (0.0%) | 0.338 |
CVD, n (%) | 17 (24.6%) | 4 (21.1%) | 1.000 |
CNS Diseases, n (%) | 11 (15.9%) | 2 (10.5%) | 0.726 |
Burn, n (%) | 7 (10.1%) | 4 (21.1%) | 0.242 |
Abdominal Operation, n (%) | 32 (46.4%) | 6 (31.6%) | 0.302 |
Asthma/COPD, n (%) | 3 (4.3%) | 2 (10.5%) | 0.294 |
Sepsis-1, n (%) | 6 (8.6%) | 3 (15.7%) | 0.196 |
History of hospitalization in the last 3 months, n (%) | 44 (63.8%) | 12 (63.2%) | 1.000 |
Chemotherapy treatment, n (%) | 18 (26.1%) | 8 (42.1%) | 0.255 |
Antimicrobial exposure in the last 90 days | |||
Carbapenem, n (%) | 45 (65.2%) | 13 (68.4%) | 1.000 |
Glycopeptide, n (%) | 36 (52.2%) | 8 (42.1%) | 0.605 |
4th generation cephalosporin, n (%) | 11 (15.9%) | 1 (5.3%) | 0.449 |
3rd generation cephalosporin, n (%) | 1 (1.4%) | 1 (5.3%) | 0.387 |
Fluoroquinolone, n (%) | 6 (8.7%) | 1 (5.3%) | 1.000 |
Aminoglycoside, n (%) | 13 (18.8%) | 4 (21.1%) | 1.000 |
Colistin, n (%) | 8 (11.6%) | 3 (15.8%) | 0.697 |
Tigecycline, n (%) | 4 (5.8%) | 0 (0.0%) | 0.573 |
Anti-pseudomonal penicillin, n (%) | 6 (8.7%) | 2 (10.5%) | 1.000 |
Linezolid, n (%) | 7 (10.1%) | 3 (15.8%) | 0.445 |
Daptomycin, n (%) | 5 (7.2%) | 0 (0.0%) | 0.581 |
Trimethoprim-sulfomethoxazole, n (%) | 5 (7.2%) | 3 (15.8%) | 0.362 |
Fluconazole, n (%) | 13 (18.8%) | 7 (36.8%) | 0.124 |
Invasive Procedures | |||
CVC, n (%) | 66 (95.7%) | 19 (100.0%) | 1.000 |
TPN, n (%) | 53 (76.8%) | 17 (89.5%) | 0.339 |
Urinary Catheter, n (%) | 59 (85.5%) | 17 (89.5%) | 1.000 |
Nephrostomy Catheter, n (%) | 3 (4.3%) | 1 (5.3%) | 1.000 |
Colostomy, n (%) | 21 (30.4%) | 1 (5.3%) | 0.054 |
CVC Remove, n (%) | 60 (87.0%) | 13 (68.4%) | 0.065 |
Microbiological Cure, n (%) | 64 (92.8%) | 8 (42.1%) | < 0.001 |