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Table 3 Overview of national and local IPC measures for multidrug-resistant Gram-negative bacteria in the Netherlands

From: Infection prevention and control without borders: comparison of guidelines on multidrug-resistant organisms in the northern Dutch-German cross-border region

IPC measures

SRI-NL

UMCG

screening criteria

patients

• 1with recent healthcare facility stays abroad

• who had invasive procedures abroad

• come from another Dutch healthcare facility with an ongoing uncontrolled outbreak

• lived in a refugee shelter < 2 months ago.

• stricter with Dutch hospital rules (screening regardless of an ongoing outbreak)

• additional recommendations for refugees/asylum seekers, adopted child, long-stay and dialyzed patients.

• known / contact of ESBL-E/CPE/CRE carrier.

sampling site

rectum/perirectum/faeces sample

2rectum

management of carriers

ESBL-E

• contact isolation

• contact precautions in multiple rooms allowed if no single room is available, with a 1.5 m bed clearance

CRE/CPE

contact isolation

ESBL-E

• contact isolation

• ESBL-producing E. coli: island nursing

CRE/CPE

3contact-plus isolation

lifting the isolation

ESBL-E

2 negative results starting 3 months after the last positive culture

CRE/CPE

• 2 negatives starting 1 year after the last positive culture

• Follow-up cultures for admissions in the first year after carrier status termination

ESBL-E

4same as SRI

CRE/CPE

same as SRI

readmission of a known MDRGN patient

No recommendation

ESBL-E

procedures differ between ESBL-producing E. coli and the other Enterobacterales for declaring negative, lifting isolation based on the number of known negatives and the time since the last positive culture

CRE/CPE

• uptake screening and isolation

• no difference among different microorganisms

• conditions for lifting the isolation are stricter

recommended PPE for HCWs

gloves, long-sleeved apron

same as SRI

  1. HCW, healthcare worker; NL, the Netherlands; PCR, polymerase chain reaction; PPE, personal protective equipment; SRI, Samenwerkingsverband Richtlijnen Infectiepreventie; UMCG, University Medical Center Groningen
  2. 1 for the individuals who have been to Asia and/or Africa < 2 months ago without healthcare facility stays: healthcare institutions are recommended to choose to include this group in the risk inventory depending on the local situation
  3. 2 in case of specific situation: sputum culture in intubated patients and in patients giving up sputum, smear of wounds and skin lesions (e.g., eczema or psoriasis), urine culture in patients with indwelling catheters or suspected urinary tract infection, umbilical smear in neonates (as long as the umbilical stump has not dried in)
  4. 3 cleaning and disinfection of the room and waste are handled differently, the patient lies in a sluiced room with the doors closed, allowing better differentiation between the clean and dirty zone
  5. 4for ESBL K. pneumoniae: 2 negatives starting 1 year after the last positive culture