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Table 1 Comparison of proportions of positive screening sites of CPE versus CPNF

From: Screening sites for detection of carbapenemase-producers– a retrospective cohort study

Localization

CPE N = 115

CPNF N = 43

Univariable analysis

Multivariable correction for CCI Scored

 

All N (%)

Positive

N (%)

Negative

N (%)

All N (%)

Positive

N (%)

Negative

N (%)

ORe (95%CI), p-valuef

ORe (95%CI), p-valuef

Screening samples (N = 453)

Rectal swab

98 (85.2)

75 (76.5)

23 (23.5)

29 (67.4)

12 (41.4%)

17 (58.6)

4.62 (1.93–11.07), 0.001

4.58 (1.82–11.53), 0.001

Perianal swab

2 (1.7)

2 (100.)

0

0

0

0

  

Urine

Urinary cathetera

72 (62.6)

20 (17.4)

25 (34.7)

7 (35.0)

47 (65.3)

13 (65.0)

25 (58.1)

9 (20.9)

3 (12.0)

0 (0.0)

22 (88.0)

9 (100)

3.90 (1.06–14.32), 0.040

4.68 (1.20–18.26), 0.026

Groin swab

45 (39.1)

23 (51.1)

22 (48.9)

12 (27.9)

4 (33.3)

8 (66.7)

2.09 (0.55–7.95), 0.279

 

Throat swab

43 (37.4)

11 (25.6)

32 (74.4)

15 (34.9)

9 (60.0)

6 (40.0)

0.23 (0.07–0.79), 0.020

0.20 (0.05–0.76), 0.018

Chronic wound swabb

11 (9.6)

4 (36.4)

7 (63.6)

9 (20.9)

8 (88.9)

1 (11.1)

0.07 (0.01–0.80), 0.032

0.04 (0.00–0.72), 0.029

Acute wound swabc

33 (28.7)

9 (27.3)

24 (72.7)

16 (37.2)

11 (68.8)

5 (31.3)

0.17 (0.05–0.63), 0.008

0.16 (0.04–0.63), 0.009

Vaginal swab

2 (1.7)

2 (100)

0

1 (2.3)

0

1 (100)

 

Insertion site vascular catheter

22 (19.1)

0

22 (100)

12 (27.9)

1 (8.3)

11 (91.7)

 

Insertion site drainage

3 (2.6)

3 (100)

0

3 (7.0)

0

3 (100)

 

Clinical samples (N = 79)

Abscess

 

4 (3.5)

  

0

 

 

Ascites

 

1 (0.9)

  

0

 

 

Blood culture

 

7 (6.1)

  

6 (14.0)

 

0.40 (0.13–1.27) 0.119

 

Biopsy

 

10 (8.7)

  

4 (9.3)

 

0.93 (0.28–3.13), 0.905

 

Deep swab

 

10 (8.7)

  

1 (2.3)

 

4.00 (0.50–32.20), 0.193

 

Respiratory sample

 

7 (6.1)

  

16 (37.2)

 

0.11 (0.04–0.29), < 0.001

0.11 (0.04–0.34), < 0.001

Urine

Urinary cathetera

 

12 (10.4)

2 (1.7)

  

1 (2.3)

1 (2.3)

 

4.89 (0.62–38.83), 0.133

0.74 (0.07–8.41), 0.811

 
  1. Significant p-values are indicated in bold and defined as a p-value < 0.05
  2. CPE, carbapenemase-producing Enterobacterales; CPNF, carbapenemases-producing non-fermenting bacteria
  3. a in place at time of sampling, transurethral or suprapubic
  4. b Ulcers, decubiti
  5. c e.g. traumatic wounds, surgical wounds
  6. d CCI-Score OR 1.70 (95%CI 1.34–2.14), p-value < 0.001, see supplementary Table 3
  7. e OR (Odds ratio) > 1 indicates higher odds for colonization with CPE, while OR < 1 indicates higher odds for colonization with CPNF