External validation of the ICU-CARB score to predict carbapenem-resistant gram-negative bacteria carriage in critically ill patients upon ICU admission: a multicenter analysis

Table 1 Baseline characteristics of the study cohort

	All (n = 2417)	Cohort I (n = 815)	Cohort II (n = 1602)	p
CRGNB carrier (%)	289 (12.0)	98 (12.0)	191 (11.9)	0.942
Female (%)	975 (40.3)	312 (38.3)	663 (41.4)	0.141
Age (mean (SD))	65.3 (18.9)	66.0 (16.7)	65.0 (19.8)	0.221
APACHE.II (median [IQR])	12 [8, 18]	12 [9, 16]	15 [10, 20]	< 0.001
SOFA (median [IQR])	3 [1, 6]	3 [2, 5]	5 [2, 8]	< 0.001
Department (%)				< 0.001
surgical	1488 (61.6)	557 (68.3)	931 (58.1)
medical	476 (19.7)	36 (4.4)	440 (27.5)
emergency	453 (18.7)	222 (27.2)	231 (14.4)
ICU mortality (%)	255 (10.6)	74 (9.1)	181 (11.4)	0.082
Variables
Neurological disease (%)	167 (6.9)	88 (10.8)	79 (4.9)	< 0.001
High-risk departments history (%) ^a	1201 (49.7)	560 (68.7)	641 (40.0)	< 0.001
LOS before ICU admission ≥ 14 (%)	511 (21.1)	74 (9.1)	437 (27.3)	< 0.001
Previous ICU admission (%) ^b	228 (9.4)	64 (7.9)	164 (10.2)	0.058
Invasive mechanical ventilation (%)	1407 (58.2)	649 (79.6)	758 (47.3)	< 0.001
Gastrointestinal tube (%)	1078 (44.6)	207 (25.4)	871 (54.3)	< 0.001
Carbapenem usage (%) ^c	689 (28.5)	118 (14.5)	571 (35.6)	< 0.001

CR-GNB, Carbapenem-resistant Gram-negative bacteria; APACHE, acute physiology and chronic health evaluation; SOFA, sequential organ failure assessment; LOS, length of stay; ICU, intensive care unit. ^a Within last month prior to ICU admission. ^b Administration for more than 3 days within last 2 months prior to ICU admission. ^c Intravenous administration of antibiotics within last 14 days prior to ICU admission

ISSN: 2047-2994