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Table 2 Onset of infection, organism, days of antibiotics used

From: The burden of left ventricular assist device (LVAD) infections on costs, lengths of stay, antimicrobial consumption and resistance: a prospective case control approach

Median time to infection

Days

First Infection

n = 67

[IQR]

Predominant Organisms

Antibiotic DOT Total, median, [IQR]

 

Second

Infection

n = 38

[IQR]

Predominant Organisms

Antibiotic DOT Total, median, [IQR]

Total

Mean total /Person

All infections 67

97.5

[37–365]

 

2063;

16.5

[10–42]

All

38

158.5

[37–257]

 

1897

37.5

[14-66.5]

3960

59.1

Uncomplicated percutaneous lead (PL) ( i.e. superficial PL) 31

142

[40–404]

No CX: 16

MSSA 9/15

CoNS 3/15

Coryn 2/15

All others 1/15 each*

932

10

[8.5–28.5]

Superficial

20

68.5

[32–224]

No Culture 6

MSSA 3/14

MRSA 2/14

Coryn. 1

Staph sp. 1

Strep 1

Gram negs 4

1031

17

[10–60]

  

Complicated percutaneous lead (deep PL, excluding bloodstream infection)

4

200

[142–390]

No growth 1/4

Poly-microbial 2/4

P. aeruginosa 3/4

227

79

[27-160.5]

Deep

3

156

[171–206]

S. epidermatus

S. pyogenese

P. aeruginosa

Coryne

MSSA

72

47.2 mean

  

Bloodstream infection

24

64

[41–434]

Streptococcal

spp. 5/24

CoNS 4/24

E. fecalis 3/24

MSSA 2/24

MRSA 2/24

K. pneumonia 2/24

All others** 1/24

737

30

[15–51]

Blood contacting surface

7

214

[56–303]

C. glabrata 2

Weisella confusa 1

P. aeruginosa 1

MRSA 1

E. coli

MSSA

627

49

[19–100]

  

Surgical

site infection

8

15.5

[9.5–46.5]

No CX 2

No growth 1/6

All other*** 1/6

167

14

[11.5–46]

SSI

2

174

[39-648.5]

No cultures 2/2

167

71

[14–83]

  
  1. External surface of implanted component (pump / pump pocket) CONS = 0 infections
  2. *Methicillin resistant Staphylococcus aureus, Providencia rettgeri, Arcanobacterium hemolyticum, Enterococcus faecalis, Klebsiella pneumonia
  3. ** Streptococcus anginosus, methicillin resistant Staphylococcus aureus, actinomyces, ESBL E. coli, Streptococcus pneumoniae, Streptococcus parasanguinous, Streptococcus parassangunosus Streptococcus constellatus, Pseudomonas aeruginosa, corynebacterium micrococcus Streptococcus viridans, micrococcus
  4. *** Staphylococcus epidermidis, Klebsiella Pneumo Candida glabrata, Streptococcus dysgalactiae, Streptococcus mitis oralis, Streptococcus para sanguinous, bacillus species, Peptostreptococus
  5. CX = culture; CONS = Coagulase negative Staphylococcus species; Coryne = Corynebacterium; MSSA Methicillin Sensitive Staphylococcus aureus; MRSA Methicillin Resistant Staphylococcus aureus