Oral vancomycin use and incidence of vancomycin-resistant enterococci: time-series analysis

Table 2 Association between antibiotic use and hospital-acquired VRE incidence

		Univariate analysis			Multivariate analysis
Variable	Lag	Coefficient	95% CI	P-value	Coefficient	95% CI	P-value
Oral vancomycin	0	0.0191	0.0017 to 0.0364	0.0312	0.0160	0.0030 to 0.0290	0.0162
IV vancomycin	6	-00.004	-0.0120 to 0.0039	0.3164	-0.0048	-0.0107 to 0.0011	0.1120
Teicoplanin	0	-0.0019	-0.0114 to 0.0076	0.6916	0.0048	-0.0030 to 0.0127	0.2269
Metronidazole	4	-0.0009	-0.0048 to 0.0029	0.6292	-0.0015	-0.0048 to 0.0017	0.3549
Fluoroquinolones	5	-0.0028	-0.0075 to 0.0020	0.2496	0.001	-0.0027 to 0.0048	0.5927
Cefazolin	0	0.00003	-0.0023 to 0.0024	0.9808	-0.0001	-0.0021 to 0.0019	0.9374
Cefoxitin	0	0.0002	-0.0066 to 0.0070	0.9535	-0.004	-0.0089 to 0.0009	0.1132
Cefuroxime	6	-0.0136	-0.0261 to -0.0011	0.0334	-0.0181	-0.0250 to -0.0112	< 0.0001
Broad-spectrum cephalosporins	6	-0.0018	-0.0040 to 0.0004	0.1105	-0.0009	-0.0030 to 0.0011	0.3734
Carbapenems	5	-0.0018	-0.0062 to 0.0026	0.4190	0.0029	-0.0002 to 0.0061	0.0663
Piperacillin-tazobactam	0	0.0002	-0.0043 to 0.0047	0.9227	-0.0024	-0.0057 to 0.0009	0.1560
Ampicillin-sulbactam	1	0.0171	0.0077 to 0.0265	< 0.0001	0.0148	0.0066 to 0.0230	0.0004
Tigecycline	6	-0.0031	-0.0165 to 0.0102	0.6449	0.0126	0.0012 to 0.0241	0.0303
Linezolid	0	0.0190	0.0047 to 0.0334	0.0094	0.0213	0.0089 to 0.0336	0.0007
Aminoglycosides	2	-0.0036	-0.0167 to 0.0096	0.5953	-0.0009	-0.0115 to 0.0098	0.8704
Co-trimoxazole	4	0.0101	-0.0054 to 0.0256	0.2010	0.0013	-0.0117 to 0.0143	0.8463
Colistin	5	0.0002	-0.0139 to 0.0142	0.9795	-0.0003	-0.0113 to 0.0107	0.9578
Baseline VRE carriage rate	0	0.0476	-0.5890 to 0.6843	0.8834	0.3640	-0.1986 to 0.9266	0.2048

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