Prevalence and molecular characterization of ESBL-producing Enterobacteriaceae in Egypt: a systematic review and meta-analysis of hospital and community-acquired infections

Azzam, Ahmed; Khaled, Heba; Samer, Dareen; Nageeb, Wedad M.

doi:10.1186/s13756-024-01497-z

Antimicrobial Resistance & Infection Control

Table 1 Characteristics of the included studies

From: Prevalence and molecular characterization of ESBL-producing Enterobacteriaceae in Egypt: a systematic review and meta-analysis of hospital and community-acquired infections

Last Name of First Author [citation]	Study period	Location	Total Sample Size	Bacteria Tested	ESBL positive	Type of infection (Community Vs. Nosocomial) *	Specimen	Phenotypic Detection OF ESBL
Khater, 2014 [59]	2012–2013	Benha	45	E. coli	24	Both	Urine	CDT
Shaaban, 2022 [50]	2021	Cairo	58	Proteus	30	NS	Urine, Wound, Blood, Sputum, CSF	DDST
Ragab, 2024 [39]	NS	Benha	41	E. coli	34	Both	Urine	Disk Diffusion, DDST
Masoud, 2022 [40]	NS	Minia	60	E. coli	37	NS	Urine	CDT
Essawy, 2018 [37]	2017	Tanta	44	E. coli	37	Both	Urine	DDST, MDDST, ESBL E-Test
ElTaweel, 2024 [34]	2021–2022	Mansoura	66	Proteus mirabilis	38	NS	Various Clinical Sources	CDT
Gaballah, 2023 [38]	NS	Alexandria	50	K. pneumoniae	39	NS	Various Clinical Specimens	Disk Diffusion, DDST
Abd El-Hamid, 2010 [32]	2009–2010	Zagazig	68	E. coli, K. pneumoniae, Enterobacter, Proteus, Serratia, Citrobacter	45	Nosocomial	Blood, Urine, CSF, Endotracheal Tube Aspirates.	DDST
Abdallah, 2015 [53]	2013	Zagazig	94	E. coli, K. pneumoniae, Enterobacter, Citrobacter, Serratia, Proteus	46	Nosocomial	Blood	Vitek 2 System, CDT
Abdel-Moaty, 2016 [57]	2012	Cairo	90	E. coli	47	Both	Mostly urine	CDT
Rashwan, 2023 [42]	2022–2023	Assiut	73	E. coli	47	Community	Stool	Vitek 2 System
Zaki, 2019 [48]	2016–2018	Mansoura	88	E. coli	49	Nosocomial	Blood	DDST, CDT
Elsayed, 2024 [45]	2019–2020	Mansoura	105	E. coli, K. pneumoniae, Enterobacter, Serratia, Proteus	50	Nosocomial	Urine, Respiratory Tract Infections, Wound Infections, Blood	DDST
EL-Ganiny, 2016 [60]	NS	Zagazig	100	K. pneumoniae	50	NS	Surgical Wounds, Urinary Catheters, Burns, Blood, Sputum	DDST
El-Mahdy, 2015 [43]	2011–2012	Cairo	112	K. pneumoniae	52	Both	Sputum, Stool, Blood, Urine, Pus	DDST, CDT
Sharaf, 2024 [46]	NS	Cairo	115	K. pneumoniae	53	NS	Blood Culture, Endotracheal and Sputum Culture, Urine, Wound Swabs	Disk Diffusion, CDT
Al-Sayed, 2018 [63]	2016–2017	Zagazig	112	E. coli	56	Community	Urine	DDST
Essam, 2011 [31]	NS	Mansoura	86	E. coli, K. pneumoniae	60	NS	Urine	DDST
Abd El-Aziz, 2021 [44]	NS	Mansoura	80	E. coli, K. pneumoniae, Enterobacter	67	NS	Urine, Sputum	MDDST
Makled, 2016 [64]	2013–2015	Menoufia	120	E. coli, K. pneumoniae, Enterobacter, Proteus, Citrobacter, Serratia	67	Nosocomial	Urine	Disk Diffusion, CDT
Alshaikh [62]	2021–2022	Tanta	100	E. coli	67	NS	Urine	DDST
Thabit, 2011 [35]	2009	Assiut	136	E. coli	72	Both	Urine	CDT, DDST, ESBL-E-Test
El Maghraby, 2024 [36]	2020–2022	Zagazig	128	E. coli	73	Nosocomial	Urine	CDT
Rizk, 2022 [33]	2021	Mansoura	100	E. coli	74	Nosocomial	Urine	Disk Diffusion, DDST
Hassuna, 2020 [51]	2016–2018	Minia	134	E. coli	80	Community	Urine	MDDST, CHROMagar ESBL
Fam, 2010 [61]	2007–2008	Cairo	520	E. coli, K. pneumoniae	83	Both	Mostly Urine	DDST
Khalifa, 2019 [47]	2014	Multiple locations in Egypt	126	E. coli, K. pneumoniae, Serratia, Salmonella, Morganella morganii	95	Nosocomial	Blood, Urine, Respiratory Sputum, Pus	Disk Diffusion
El-Shalakany, 2014 [52]	NS	Menoufia	160	E. coli, K. pneumoniae, Enterobacter, Citrobacter, Serratia, Proteus	97	NS	Urine, Sputum, Stool, Blood, Pus	Disk Diffusion, PCDDT
Shash, 2019 [55]	2016–2017	Cairo	250	E. coli, K. pneumoniae	100	Both	Urine	Disk Diffusion, DDST, CDT
Ibrahim, 2014 [54]	2014	Assiut	143	K. pneumoniae	108	Both	Urine	DDST, CDT, ESBL-E-Test
Amer, 2019 [49]	2016–2018	Cairo	168	E. coli, K. pneumoniae	113	NS	Urine, Pus, Blood, Sputum, Semen, Stool	DDST, CDT
Mohamed, 2020 [56]	2018	Minia	440	E. coli, K. pneumoniae, Enterobacter, Citrobacter, Proteus	311	Community	Urine	Disk Diffusion, DDST
El Kholy, 2011 [41]	2008–2010	Cairo	456	E. coli, K. pneumoniae	326	Nosocomial	Blood, Urine, Sputum, Pus	DDST, CDT
Salama, 2021 [58]	2016–2017	Mansoura	60	Proteus mirabilis	17	Both	Urine	MDDST

CDT: Combination Disk Test; DDST: Double Disk Synergy Test; MDDST: Modified Double Disk Synergy Test; ESBL E-Test: Extended Spectrum Beta-Lactamase E-Test; PCDDT: Phenotypic Confirmatory Disk Diffusion Test, NS: Not specified
* All the unspecified studies were hospital-based, but the source of infection, whether community-acquired or hospital-acquired, was not specified

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ISSN: 2047-2994

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