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Table 3 Risk factors for the acquisition of carbapenem-resistant Enterobacterales

From: Impact of universal contact precautions and chlorhexidine bathing on the acquisition of carbapenem-resistant enterobacterales in the intensive care unit: a cohort study

Variable

Univariate analysis

Multivariate analysis

HR

95% CI

P-value

aHR

95% CI

P-value

Age

      

≤65 years

1

     

>65 years

1.113

0.544–2.278

0.769

   

Sex

      

Male

1

     

Female

1.035

0.524–2.044

0.922

   

Charlson comorbidity index

      

≤3

1

  

1

  

>3

1.756

0.886–3.482

0.107

1.478

0.729-3.000

0.279

SOFA score

      

≤6

1

     

>6

0.623

0.297–1.308

0.211

   

Carbapenem

      

Not exposed

1

  

1

  

Exposed

2.753

1.332–5.691

0.006

2.555

1.208–5.403

0.014*

Beta-lactam and beta-lactamase inhibitor

      

Not exposed

1

     

Exposed

1.031

0.507-2.100

0.932

   

Third- or fourth-generationcephalosporin

      

Not exposed

1

     

Exposed

0.866

0.419

1.789

   

Vancomycin

      

Not exposed

1

     

Exposed

1.209

0.605–2.413

0.591

   

Fluoroquinolone

      

Not exposed

1

     

Exposed

0.830

0.405–1.702

0.612

   

Mechanical ventilation

      

Not applied

1

     

Applied

0.691

0.310–1.542

0.367

   

Tracheostomy

      

Not performed

1

     

Performed

0.912

0.437–1.902

0.805

   

Central venous catheter

      

Not applied

1

     

Applied

1.196

0.518–2.761

0.675

   

Tube feeding

      

Not applied

1

     

Applied

0.875

0.293–2.620

0.812

   

Urinary catheter

      

Not applied

1

     

Applied

0.845

0.297–2.407

0.753

   

CRRT

      

Not applied

1

  

1

  

Applied

1.610

0.798–3.251

0.184

1.144

0.548–2.389

0.721

Number of CRE colonisers present during ICU stay

      

≤4

1

  

1

  

>4

2.715

1.256–5.869

0.011*

2.639

1.226–5.684

0.013*

Universal contact precautions and CHG bathing

      

Before intervention

1

  

1

  

After intervention

0.696

0.320–1.513

0.360

0.657

0.301–1.433

0.291

  1. *P < 0.05; HR, hazard ratio; aHR, adjusted hazard ratio; CI, confidence interval; SOFA, Sequential Organ Failure Assessment; CRRT, continuous renal replacement therapy; CRE, carbapenem-resistant Enterobacterales; ICU, intensive care unit; CHG, chlorhexidine gluconate