Variable | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|
HR | 95% CI | P-value | aHR | 95% CI | P-value | |
Age | ||||||
≤65 years | 1 | |||||
>65 years | 1.113 | 0.544–2.278 | 0.769 | |||
Sex | ||||||
Male | 1 | |||||
Female | 1.035 | 0.524–2.044 | 0.922 | |||
Charlson comorbidity index | ||||||
≤3 | 1 | 1 | ||||
>3 | 1.756 | 0.886–3.482 | 0.107 | 1.478 | 0.729-3.000 | 0.279 |
SOFA score | ||||||
≤6 | 1 | |||||
>6 | 0.623 | 0.297–1.308 | 0.211 | |||
Carbapenem | ||||||
Not exposed | 1 | 1 | ||||
Exposed | 2.753 | 1.332–5.691 | 0.006 | 2.555 | 1.208–5.403 | 0.014* |
Beta-lactam and beta-lactamase inhibitor | ||||||
Not exposed | 1 | |||||
Exposed | 1.031 | 0.507-2.100 | 0.932 | |||
Third- or fourth-generationcephalosporin | ||||||
Not exposed | 1 | |||||
Exposed | 0.866 | 0.419 | 1.789 | |||
Vancomycin | ||||||
Not exposed | 1 | |||||
Exposed | 1.209 | 0.605–2.413 | 0.591 | |||
Fluoroquinolone | ||||||
Not exposed | 1 | |||||
Exposed | 0.830 | 0.405–1.702 | 0.612 | |||
Mechanical ventilation | ||||||
Not applied | 1 | |||||
Applied | 0.691 | 0.310–1.542 | 0.367 | |||
Tracheostomy | ||||||
Not performed | 1 | |||||
Performed | 0.912 | 0.437–1.902 | 0.805 | |||
Central venous catheter | ||||||
Not applied | 1 | |||||
Applied | 1.196 | 0.518–2.761 | 0.675 | |||
Tube feeding | ||||||
Not applied | 1 | |||||
Applied | 0.875 | 0.293–2.620 | 0.812 | |||
Urinary catheter | ||||||
Not applied | 1 | |||||
Applied | 0.845 | 0.297–2.407 | 0.753 | |||
CRRT | ||||||
Not applied | 1 | 1 | ||||
Applied | 1.610 | 0.798–3.251 | 0.184 | 1.144 | 0.548–2.389 | 0.721 |
Number of CRE colonisers present during ICU stay | ||||||
≤4 | 1 | 1 | ||||
>4 | 2.715 | 1.256–5.869 | 0.011* | 2.639 | 1.226–5.684 | 0.013* |
Universal contact precautions and CHG bathing | ||||||
Before intervention | 1 | 1 | ||||
After intervention | 0.696 | 0.320–1.513 | 0.360 | 0.657 | 0.301–1.433 | 0.291 |