Table 2 Comparison of baseline characteristics between pre-and post-intervention groups

Age, years (IQR)

69 (54, 79)

70 (57, 79)

0.027*

Sex, M (%)

253 (56.1%)

727 (56.1%)

1.000

Body mass index (kg/m²) (IQR)

22.4 (19.5, 25.2)

22.2 (19.5, 25.0)

0.661

Charlson comorbidity index (IQR)

2 (1, 4)

2 (1,4)

0.135

SOFA score (IQR)

7 (5, 10)

8 (5, 11)

0.023*

Single-room occupancy

10 (2.2%)

45 (3.5%)

0.213

Number of CRE colonisers present during ICU stay

3 (2, 3)

2 (1, 3)

0.184

Prior exposure to antibiotics

Beta-lactam and beta-lactamase inhibitor

240 (53.2%)

722 (55.7%)

0.379

First-generation cephalosporin

80 (17.7%)

175 (13.5%)

0.030*

Second-generation cephalosporin

10 (2.2%)

40 (3.1%)

0.414

Third-generation cephalosporin

107 (23.7%)

254 (19.6%)

0.068

Fourth-generation cephalosporin

44 (9.8%)

125 (9.6%)

1.000

Aminoglycoside

7 (1.6%)

18 (1.4%)

0.819

Fluoroquinolone

112 (24.8%)

321 (24.8%)

1.000

Carbapenem

94 (20.8%)

362 (27.9%)

0.003*

Vancomycin

119 (26.4%)

338 (26.1%)

0.901

Therapeutic variables

Mechanical ventilation

224 (49.7%)

678 (52.3%)

0.352

Tracheostomy

55 (12.2%)

202 (15.6%)

0.089

Central venous catheter

256 (56.8%)

849 (65.5%)

0.001*

Feeding tube

262 (58.1%)

819 (63.2%)

0.056

Urinary catheter

395 (87.6%)

1144 (88.3%)

0.736

Continuous renal replacement therapy

85 (18.8%)

242 (18.7%)

0.944

Duration of hospital stay

Length of ICU stay (days) (IQR)

6 (4, 11)

7 (4, 14)

0.128

CRE acquisition

9 (2.0%)

26 (2.0%)

1.000

In-hospital mortality

142 (31.5%)

392 (30.2%)

0.635