Fig. 2

Phylogenetic tree of 278 MDR/RR-TB strains isolated in Sichuan. Note the different colors on the branches indicate different sub-lineages. The first outer circle indicates the presence or absence of RpoB S450L. The second outer circle indicates the presence or absence of KatG S315T. The small circles of different colors on the outer middle ring indicate drug resistance. The outer-most circle indicates genomic-clustered strains differing by ≤ 12 SNPs. L2.2, lineage 2.2; L4.5, lineage 4.5; L4.4, lineage 4.4; L4.2, lineage 4.2. MDR/RR-TB, Multidrug-resistant or rifampicin-resistant tuberculosis