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Table 3 Factors associated with risk of culture un-conversion within 6 months of treatment in all patients

From: Predictors of early and interim culture un-conversion in multidrug-resistant/rifampicin-resistant tuberculosis: a retrospective multi-center cohort study in China

Predictor

Sputum culture un-conversion within 6 months of treatment in univariate analysis

Sputum culture un-conversion within 6 months of treatment in multivariate analysis

Odds ratio

(95% CI)

P value

Adjusted odds ratio

(95% CI)

P value

Male

2.010 (1.338–3.018)

0.001

-

0.068

Age

1.018 (1.006–1.029)

0.002

-

0.447

BMI<18.5 kg/m2

1.753 (1.217–2.523)

0.003

-

0.056

Ever smoker

2.358 (1.613–3.447)

<0.001

2.197 (1.475–3.273)

<0.001

Alcohol history

1.996 (1.407–2.832)

<0.001

-

0.218

Previously treated for TB

1.971 (1.356–2.866)

<0.001

1.909 (1.282–2.844)

0.001

AFB smear positive

1.427(0.984–1.427)

0.061

-

0.695

Cavitary disease

1.639 (1.126–2.386)

0.010

-

0.212

Bilateral disease

2.459 (1.556–3.884)

<0.001

2.201 (1.369–3.537)

0.001

Anemia

1.388(0.964–1.998)

0.078

-

0.269

Viral hepatitis

2.063 (1.036–4.109)

0.039

2.329 (1.094–4.962)

0.028

Regimen containing BDQ

0.405 (0.258–0.636)

<0.001

0.310 (0.191–0.502)

<0.001

  1. Abbreviations: BDQ, bedaquiline; CI, confidence interval; MDR/RR-TB, multidrug-resistant/ rifampin-resistant tuberculosis; TB, tuberculosis