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Table 2 Factors associated with risk of culture un-conversion within 2 months of treatment in MDR/RR-TB patients

From: Predictors of early and interim culture un-conversion in multidrug-resistant/rifampicin-resistant tuberculosis: a retrospective multi-center cohort study in China

Predictor

Sputum culture un-conversion within 2 months of univariate analysis

Sputum culture un-conversion within 2 months of multivariate analysis

Odds ratio

(95% CI)

P value

Adjusted odds ratio

(95% CI)

P value

Male

1.211(0.902–1.626)

0.203

-

0.500

Age

1.001(0.992–1.011)

0.757

-

0.628

BMI<18.5 kg/m2

1.413 (1.033–1.932)

0.030

-

0.172

Ever smoker

1.580 (1.116–2.236)

0.010

-

0.058

Alcohol history

1.407 (1.046–1.892)

0.024

-

0.187

Previously treated for TB

1.543 (1.163–2.046)

0.003

-

0.083

AFB smear positive

2.021 (1.510–2.705)

<0.001

1.637 (1.197–2.238)

0.002

Cavitary disease

1.856 (1.391–2.477)

<0.001

1.539 (1.132–2.092)

0.006

Bilateral disease

1.923 (1.409–2.625)

<0.001

1.638 (1.183–2.269)

0.003

Anemia

1.461 (1.073–1.991)

0.016

-

0.105

Viral hepatitis

2.419 (1.163–5.032)

0.018

2.585 (1.189–5.622)

0.017

Regimen containing BDQ

0.809(0.596–1.098)

0.174

-

0.072

  1. Abbreviations: AFB, acid-fast bacilli; BDQ, bedaquiline; BMI, body mass index; CI, confidence interval; MDR/RR-TB, multidrug-resistant/ rifampin-resistant tuberculosis; TB, tuberculosis