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Table 1 Predictors for early and interim sputum culture conversion in MDR/RR-TB patients

From: Predictors of early and interim culture un-conversion in multidrug-resistant/rifampicin-resistant tuberculosis: a retrospective multi-center cohort study in China

Predictor

overall

Sputum culture conversion within 2 months of treatment

Sputum culture conversion within 6 months of treatment

Yes

No

P value

Yes

No

P value

Patients

813

362(44.5%)

451(55.5%)

-

649(79.8%)

164(20.2%)

-

Socio-demographic characteristics

       

 Male

549(67.5%)

236(65.2%)

313(69.4%)

0.203

420(64.7%)

129(78.7%)

0.001

 Age, median (Q1, Q3) (year)

37.00(27.00, 52.00)

36.00(27.00, 52.00)

38.00(27.00, 52.00)

0.564

36.00(27.00, 51.00)

43.50(28.00, 56.75)

0.003

 >60 years

102(12.5%)

47(13.0%)

55(12.2%)

0.736

72(11.1%)

30(18.3%)

0.013

BMI (Q1, Q3) (kg/m2)*

20.31(18.17, 22.28)

20.53(18.52, 22.31)

20.05(17.96, 22.28)

0.057

20.51(18.36, 22.48)

19.75(17.44, 21.45)

0.001

 <18.5 kg/m2 (underweight)

228(28.4%)

88(24.6%)

140(31.5%)

0.030

167(26.0%)

61(38.1%)

0.002

 Rural

393(48.3%)

169(46.7%)

224(49.7%)

0.398

316(48.7%)

77(47.0%)

0.690

 Farmer

139(17.1%)

60(16.6%)

79(17.5%)

0.723

119(18.3%)

20(12.2%)

0.062

MDR/RR-TB risk facters

       

 Ever smoker

173(21.3%)

62(17.1%)

111(24.6%)

0.010

117(18.0%)

56(34.1%)

<0.001

 Alcohol history

272(33.5%)

106(29.3%)

166(36.8%)

0.024

196(30.2%)

76(46.3%)

<0.001

 Previously treated for TB

485(59.7%)

195(53.9%)

290(64.3%)

0.003

367(56.5%)

118(72.0%)

<0.001

TB-related characteristics

       

 AFB smear positive

524(64.5%)

201(55.5%)

323(71.6%)

<0.001

408(62.9%)

116(70.7%)

0.060

 Cavitary disease

514(63.2%)

200(55.2%)

314(69.6%)

<0.001

396(61.0%)

118(72.0%)

0.009

 Bilateral disease

589(72.4%)

236(65.2%)

353(78.3%)

<0.001

450(69.3%)

139(84.8%)

<0.001

Comorbidities

       

 Anemia

237(29.2%)

90(24.9%)

147(32.6%)

0.016

180(27.7%)

57(34.8%)

0.077

 DM

123(15.1%)

45(12.4%)

78(17.3%)

0.054

94(14.5%)

29(17.7%)

0.307

 Hypertension

41(5.0%)

14(3.9%)

27(6.0%)

0.170

29(4.5%)

12(7.3%)

0.136

 Viral hepatitis

39(4.8%)

10(2.8%)

29(6.4%)

0.015

26(4.0%)

13(7.9%)

0.036

Clinical symptoms

       

 Cough

705(86.7%)

301(83.1%)

404(89.6%)

0.007

557(85.8%)

148(90.2%)

0.136

 Sputum

624(76.8%)

258(71.3%)

366(81.2%)

0.001

489(75.3%)

135(82.3%)

0.059

 Fever

217(26.7%)

97(26.8%)

120(26.8%)

0.952

183(28.2%)

34(20.7%)

0.053

 Hemoptysis

184(22.6%)

84(23.2%)

100(22.2%)

0.727

147(22.7%)

37(22.6%)

0.981

 Night sweat

167(20.5%)

59(16.3%)

108(23.9%)

0.007

120(18.5%)

47(28.7%)

0.004

 Fatigue

219(26.9%)

97(26.8%)

122(27.1%)

0.935

170(26.2%)

49(29.9%)

0.342

 Weight loss

195(24.0%)

54(14.9%)

141(31.3%)

<0.001

132(20.3%)

63(38.4%)

<0.001

 Chest pain

157(19.3%)

53(14.6%)

104(23.1%)

0.003

102(15.7%)

55(33.5%)

<0.001

 Dyspnea

187(23.0%)

53(14.6%)

134(29.7%)

<0.001

123(19.0%)

64(39.0%)

<0.001

DST pattern

   

0.094

  

0.053

 MDR/RR-TB

580(71.3%)

269(74.3%)

311(69.0%)

 

473(72.9%)

107(65.2%)

 

 pre-XDR-TB

233(28.7%)

93(25.7%)

140(31.0%)

 

176(27.1%)

57(34.8%)

 

Baseline treatment regimen

   

0.174

  

<0.001

 Regimen containing BDQ

232(28.5%)

112(30.9%)

120(26.6%)

 

206(31.7%)

26(15.9%)

 

 Regimen without BDQ

581(71.5%)

250(69.1%)

331(73.4%)

 

443(68.3%)

138(84.1%)

 
  1. Abbreviations: AFB, acid-fast bacilli; BDQ, bedaquiline; BMI, body mass index; DM, diabetes mellitus; DST, drug susceptibility test; MDR/RR-TB, multidrug-resistant/rifampicin-resistant tuberculosis; pre-XDR-TB, pre-extensive drug-resistant tuberculosis
  2. * Eleven cases had no BMI data, **Continuous calibration of chi-square test
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Antimicrobial Resistance & Infection Control

ISSN: 2047-2994

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