Fig. 3

Genetic relationship between Klebsiella spp. isolates. (A) SNP difference matrix of Klebsiella spp. co-harboring blaKPC−4 and blaVIM−1. The similarity of the isolates was assessed based on the chromosomal average nucleotide identity between the core genes of the isolates, with < 25 differential SNPs considered identical within the species. (B) Maximum likelihood phylogenetic tree of Klebsiella spp. isolates. The K. pneumoniae subsp. pneumoniae HS11286 was used as an outgroup to root the tree. The scale represents the number of SNPs per variable site. KP: K. pneumoniae, KV: K. variicola