Table 3 Sensitivity (Sens), specificity (Spec), positive predictive value (PPV), negative predictive value (NPV) and workload reduction for algorithms a, B, C and D
Algorithm | Sens (95% CI) | Spec (95% CI) | PPV (95% CI) | NPV (95% CI) | Workload reduction (%) |
|---|---|---|---|---|---|
Primary endpoint: all infection (superficial, deep and organ/space infections) | |||||
A | 62.9 (60.6–65.3) | 93.9 (92.7–95.0) | 28.9 (26.7–31.1) | 98.5 (97.9–99.1) | 91.7 |
B | 80.7 (78.7–82.6) | 70.2 (68.0–72.5) | 9.7 (8.2–11.1) | 98.9 (98.4–99.4) | 68.3 |
C | 85.5 (83.8–87.2) | 79.4 (77.5–81.4) | 14.1 (12.4–15.8) | 99.3 (98.9–99.7) | 76.9 |
D | 32.3 (30.0–34.5) | 98.3 (97.7–98.9) | 42.6 (40.2–45.0) | 97.4 (96.6–98.1) | 97.1 |
Secondary endpoint: only deep and organ/space infections | |||||
A | 95.0 (93.9–96.1) | 93.9 (92.7–95.1) | 28.2 (26.0–30.3) | 99.9 (99.7–100.0) | 91.7 |
B | 100.0 (100.0–100.0) | 70.0 (67.8–72.2) | 7.7 (6.4–9.0) | 100.0 (100.0–100.0) | 68.3 |
C | 97.5 (96.7–98.3) | 78.8 (76.8–80.8) | 10.4 (8.9–11.9) | 99.9 (99.8–100.0) | 76.9 |
D | 47.5 (45.1–49.9) | 98.2 (97.6–98.9) | 40.4 (38.0–42.8) | 98.7 (98.1–99.2) | 97.1 |