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Table 2 Univariate and multivariate COX regression analysis of predictors of all-cause 30 day mortality patients with CRE sepsis post ERCP.

From: Carbapenem-resistant Enterobacterales sepsis following endoscopic retrograde cholangiopancreatography: risk factors for 30-day all-cause mortality and the development of a nomogram based on a retrospective cohort

 

Univariable

Multivariable

Characteristic

HR

95% CI

p-value

HR

95% CI

p-value

Age > 80

1.88

1.19–2.98

0.007

2.61

1.53–4.47

< 0.001

Prior hospitalization within 90 days

0.93

0.52–1.67

0.800

0.69

0.36–1.30

0.246

ICU admission within 90 days

2.45

1.40–4.26

0.002

2.64

1.39–5.04

0.003

Time from ERCP to Sepsis < 2 days

1.63

1.00-2.65

0.050

1.50

0.87–2.56

0.143

Diabetes

0.90

0.50–1.62

0.732

0.70

0.37–1.32

0.272

Hypoproteinemia

2.86

1.69–4.86

< 0.001

4.55

2.48–8.34

< 0.001

Quick Pitt Bacteremia Score ≥ 2

3.53

2.20–5.67

< 0.001

2.61

1.55–4.37

< 0.001

Cholangioscope

2.11

1.17–3.80

0.013

1.48

0.80–2.75

0.211

Post ERCP pancreatitis

2.19

1.16–4.12

0.015

2.52

1.29–4.92

0.007

Post ERCP perforation

2.98

1.62–5.48

< 0.001

1.24

0.60–2.55

0.563

Inappropriate Empirical therapy

3.60

2.38–5.45

< 0.001

3.48

2.19–5.53

< 0.001

Non-early-appropriate therapy

1.89

1.14–3.13

0.014

2.64

1.52–4.60

< 0.001

Short Duration < 10 days

2.49

1.64–3.78

< 0.001

5.03

2.97–8.52

< 0.001

  1. Note: *P < 0.05 (bold values) was considered statistically significant.
  2. Abbreviations: HR = Hazard Ratio; CI = Confidence Interval; CRE, Carbapenem-resistant Enterobacterales; ERCP, Endoscopic retrograde cholangiopancreatography