Fig. 4

Changes in MICs of antibiotics against pathogens in neonatal IBIs, 2019 to 2021. a The MIC of antibiotics against Escherichia coli; b The MIC of antibiotics against GBS; c The MIC of antibiotics against Enterococcus spp.; d The MIC of antibiotics against Staphylococcus aureus. MIC, Minimum inhibitory concentration; GBS, Group B Streptococcus. Based on data of MIC for antibiotics against common pathogens in neonatal IBIs collected in 17 Chinese hospitals from 2019 to 2021. Figure 4 exhibits the changes in antibiotic MICs between 2019 and 2021. The arrows pointing to the right represent increases in proportion over time, while the arrows pointing to the left indicate decreases. If the proportion of a strain with low MIC level increased in a certain pathogen, it theoretically indicated that the susceptibility of the corresponding antibiotic to this pathogen improved during the three years, and vice versa. ^§ High-concentration gentamicin MIC (ug/ml). ^* Mantel-Haenszel linear-by-linear association chi-square test revealed a notable p for trend (p < 0.05)