Fig. 2

Trends in antimicrobial susceptibility of the most common pathogens in neonatal IBIs, 2012 to 2021. a Antimicrobial susceptibility of Escherichia coli; b Antimicrobial susceptibility of Escherichia coli and its proportion of ESBL-negative strains; c Antimicrobial susceptibility of GBS; d Antimicrobial susceptibility of Enterococcus spp.; e Antimicrobial susceptibility of Staphylococcus aureus. APC, annual percentage change; GBS, Group B Streptococcus; ESBL, extended-spectrum beta-lactamase; CI, confidence interval. Based on the annual antibiotic susceptibility data of Chinese full-term neonates with IBIs collected in 17 hospitals from 2012 to 2021. Figure 2 exhibits the B-spline fitting curves describing the temporal trends in the prevalence of antimicrobial susceptibility by the four most prevalent pathogens during these 10 years. Data points indicate the proportion of annual susceptible strains. These estimates are presented along with error bars that depict 95% CIs. The breakpoints indicate that the trend of antimicrobial susceptibility varied across different time stages. APC is estimated by Joinpoint regression, which represents the slope of each line segment