Table 1 Profile of antimicrobials for systemic use sold in Brazil from 2014 to 2019, brazilian health regulatory agency (ANVISA)
From: Consumption of antibiotics in Brazil - an analysis of sales data between 2014 and 2019
Pharmacological subgroup | ATC Code | Substance | Number of Sales | Commercial Units Sold | Consumed tons | Commercial presentations Available in Brazil | DDD (g) | WHO AWaRe classification |
|---|---|---|---|---|---|---|---|---|
Aminoglycoside Antibacterials | J01GB03 | Gentamicin (IV) | 156,016 | 355,958 | 0.07 | 28 | 0.24 | Access |
J01GB06 | Amikacin | 3,523 | 69,511 | 0.03 | 11 | 1.00 | Access | |
J01GB01 | Tobramycin (IV) | 121 | 5,620 | < 0.01 | 02 | 0.24 | Watch | |
Tobramycin (powder/solution) | 66 | 86 | < 0.01 | 04 | 0.11/0.30 | Watch | ||
Amphenicols | J01BA02 | Thiamphenicol | 107,333 | 121,665 | 0.96 | 02 | 1.50 | Access |
J01BA01 | Chloramphenicol | 25,202 | 33,961 | 0.34 | 46 | 3.00 | Access | |
Beta-Lactam Antibacterials, Penicillins | J01CA04 | Amoxicillin | 61,646,665 | 68,025,441 | 670.00 | 200 | 1.50 | Access |
J01CR02 | Amoxicillin/clavulanic Acid | 47,900,000 | 56,800,000 | 528.90 | 42 | 1.50 | Access | |
J01CE08 | Benzathine benzylpenicillin | 2,176,780 | 4,022,629 | 15.50 | 59 | 3.60 | Access | |
J01CA01 | Ampicillin | 1,481,210 | 2,136,560 | 15.20 | 56 | 2.00 | Accsess | |
J01CR02 | Amoxicillin/sulbactam | 444,903 | 487,820 | 5.02 | 15 | 1.50 | Not recommended | |
J01CE02 | Phenoxymethylpenicillin | 67,446 | 106,354 | 0.40 | 105 | 2.00 | Access | |
J01CE09 | Procaine benzylpenicillin | 1,188 | 3,686 | < 0.01 | 75 | 0.60 | Access | |
J01CE01 | Benzylpenicillin | 1,088 | 3,358 | < 0.01 | 101 | 3.60 | Access | |
J01CR05 | Piperacillin/ /tazobactam | 117 | 809 | < 0.01 | 12 | 14.00 | Watch | |
J01CF04 | Oxacilin | 46 | 374 | < 0.01 | 1 | 2.00 | Access | |
J01CR01 | Ampicillin/sulbactam | 12 | 143 | < 0.01 | 95 | 6.00 | Access | |
Drugs for treatment of tuberculosis | J04AB02 | Rifampicin | 144,169 | 355,347 | 0.64 | 6 | 0.6 | Watch |
Macrolides, Lincosamides And Streptogramins | J01FA10 | Azithromycin | 50,140,000 | 63,300,000 | 163.00 | 132 | 0.30 | Watch |
J01FA09 | Clarithromycin | 5,938,185 | 6,755,171 | 34.20 | 80 | 0.50 | Watch | |
J01FF01 | Clindamycin (Oral/IV) | 2,553,785 | 4,272,715 | 21.10 | 25 | 1.20/ 1.80 | Access | |
J01FF02 | Lincomycin | 367,748 | 926,513 | 0.50 | 04 | 1.80 | Watch | |
J01FA01 | Erythromycin | 512,335 | 623,599 | 4.40 | 28 | 1.00 | Watch | |
J01FA06 | Roxithromycin | 17 | 67 | < 0.01 | 01 | 0.30 | Watch | |
Other Antibacterials | J01XD01 | Metronidazole (IV/ Oral) | 7,819,066 | 9,573,397 | 74.80 | 48 | 1.50/2.00 | Access |
J01XX08 | Linezolid | 1,296 | 2,075 | < 0.01 | 05 | 1.20 | Reserve | |
J01XA02 | Teicoplanin (IV) | 293 | 1,344 | < 0.01 | 11 | 0.40 | Watch | |
J01XB02 | Polymyxin B (IV) | 17 | 52 | < 0.01 | 04 | 0.15 | Reserve | |
Other Beta-Lactam Antibacterials | J01DB01 | Cefalexin | 38,500,000 | 72,600,000 | 3,460.0 | 102 | 2.00 | Access |
J01DD04 | Ceftriaxone | 4,620,641 | 13,000,000 | 27.70 | 131 | 2.00 | Watch | |
J01DB05 | Cefadroxil | 5,351,102 | 9,530,943 | 39.40 | 30 | 2.00 | Access | |
J01DC04 | Cefaclor | 3,563,485 | 4,132,973 | 25.20 | 40 | 1.00 | Watch | |
J01DB03 | Cefalotin | 1006 | 4207 | 0.26 | 16 | 4.00 | Access | |
J01DH02 | Meropenem | 963 | 1,747 | 0.02 | 04 | 3.00 | Reserve | |
J01DE01 | Cefepime | 330 | 3298 | < 0.01 | 28 | 4.00 | Watch | |
J01DD02 | Ceftazidime | 182 | 2158 | < 0.01 | 13 | 4.00 | Watch | |
J01DB04 | Cefazolin | 175 | 632 | < 0.01 | 11 | 3.00 | Access | |
J01DC01 | Cefoxitin | 145 | 386 | < 0.01 | 03 | 6.00 | Watch | |
J01DF01 | Aztreonam | 86 | 210 | < 0.01 | 02 | 4.00 | Reserve | |
J01DC02 | Cefuroxime | 5 | 53 | < 0.01 | 02 | 0.50 | Watch | |
J01DD01 | Cefotaxime | 8 | 69 | < 0.01 | 05 | 4.00 | Watch | |
Quinolone Antibacterials | J01MA02 | Ciprofloxacin (Oral/ IV) | 31,545,477 | 36,110,587 | 239.14 | 142 | 1.00/0.80 | Watch |
J01MA12 | Levofloxacin | 21,389,060 | 23,886,710 | 93.94 | 70 | 0.24 | Watch | |
J01MA06 | Norfloxacin | 7,551,935 | 8,271,836 | 44.60 | 55 | 0.80 | Watch | |
J01MA14 | Moxifloxacin | 1,554,924 | 1,801,077 | 4.33 | 19 | 0.40 | Watch | |
J01MA15 | Gemifloxacin (Oral) | 96,580 | 104,562 | 0.19 | 39 | 0.32 | Watch | |
J01MA01 | Ofloxacin | 1 | 1 | < 0.01 | 1 | |||
Sulfonamides and Trimethoprim | J01EE01 | Sulfamethoxazole/trimethoprim | 11,400,000 | 15,400,000 | 106.0 | 105 | 2.00 | Access |
Tetracyclines | J01AA02 | Doxycycline | 2,856,431 | 4,462,703 | 6.84 | 23 | 0.10 | Access |
J01AA07 | Tetracycline | 766,525 | 2,793,014 | 38.50 | 60 | 1.00 | Access | |
J01AA08 | Minocycline | 169,793 | 207,017 | 0.61 | 38 | 0.20 | Watch | |
J01AA06 | Oxytetracycline | 9,189 | 23,017 | 0.09 | 04 | 1.00 | Watch | |
J01AA12 | Tigecycline | 14 | 28 | < 0.01 | 01 | 0.10 | Reserve |