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Table 2 Publication year, ABHR format, study time period, country in which the study was performed, impact on hand hygiene compliance and healthcare outcome

From: Rinse, gel, and foam – is there any evidence for a difference in their effectiveness in preventing infections?

Pub Date

First Author

ABHR Format

Time period

Country

Healthcare Outcome

2000

Pittet [46]

liquid

1993–1998

Switzerland

Significant decrease in HAIs and MRSA transmission

2004

Won [51]

liquid

1997–2001

Taiwan

Significant decrease in HAIs

2007

Pessoa-Silva [52]

liquid

Mar 2001-Feb 2004

Switzerland

Decrease in BSIs in NICU

2008

Nguyen [53]

liquid

Apr—Dec 2007

Vietnam

Significant decrease in HAIs

2009

Souweine [54]

liquid

Apr 2003-Jan 2004

France

Decrease in MRSA colonization/infection

2010

Cheng [55]

liquid

Jan 2002-Jun 2009

Hong Kong

Significant decrease in MRSA infections, including MRSA BSIs

2011

Chen [56]

liquid

Jan 1999-Dec 2007

Taiwan

Significant decrease in HAIs

2011

Barrera [57]

liquid

Feb-Jun 2002

Columbia

Significant decrease in CLABSIs, not other HAIs

2012

Monistrol [58]

liquid

Feb 2007-Jan 2008

Spain

Decrease in MRSA acquisition; no change in HAIs

2012

Ho [59]a

liquid

Nov 2009-Jul 2010

Hong Kong

Significant decrease in respiratory and MRSA infections

2012

Ling [60]

liquid

Jan 2007-Dec 2010

Singapore

Decrease (borderline) in HA-MRSA infections

2012

Lee [61]

liquid

Jan 2004-Dec 2010

Taiwan

Significant decrease in HA-MRSA infections

2015

Thi Anh Thu [62]

liquid

Jun 2009-Apr 2011

Vietnam

Significant decrease in HAIs

2015

Sadeghi-Moghaddam [63]

liquid

Apr 2010-Mar 2014

Iran

Significant decrease in HAIs

2016

Cheng [64]

liquid

Jul 2011-Oct 2015

Hong Kong

Significant decrease in VRE transmission

2017

Saito [65]

liquid

Oct 2014-Apr 2015

Uganda

Significant decrease in HAIs/SIRs in pediatric & surgical dept

2018

Allegranzi [66]

liquid

Jul 2013-Dec 2015

African countries

Significant decrease in surgical site infections

2018

Grayson [67]

liquid

2009–2017

Australia

Significant decrease in healthcare-associated S. aureus bacteremia

2019

von Lengerke [68]a

liquid

2013–2015

Germany

Significant decrease in MDROs

2019

Hagel [69]

liquid

Sep 2011-Aug 2012 May 2013-Aug 2014

Germany

No change in overall HAIs;

Significant decrease in severe ICU HAIs

2020

Aghdassi [70]a

liquid

Dec 2017-Dec 2018

Germany

Significant decrease in device-related BSIs

2020

Phan [71]

liquid

2010–2018

Vietnam

Significant decrease in HAIs

2021

Knudsen [72]

liquid

Feb 2020-Jan 2021

Denmark

Significant decrease in HAIs

2021

Lo [73]

liquid

2018-May 2020

Taiwan

Significant decrease in CRAB and VRE infections

2022

Fukushige [74]

liquid

2018–2020

Taiwan

Significant decrease in overall HAIs; not in MRSA or VRE HAIs

2022

Gonzalez-Gonzalez [75]

liquid

2009–2019

Mexico

Significant decrease in CLABSIs

2023

Rosenfeldt Knudsen [76]

liquid

Feb 2020-Jun 2022

Denmark

Significant decrease in HABSIs; no significant change in CAUTIs

2002

Fendler [77]

gel

Jul 1997-May 2000

USA

Significant decrease in HAIs

2003

Hilburn [78]

gel

Feb 2000-May2001

USA

Significant decrease in HAIs

2004

MacDonald [79]

gel

Mar 2000-Nov 2000

Scotland

Significant decrease in MRSA acquisition

2007

Murthy [80]

gel

1999–2003

USA

Significant decrease in nosocomial MRSA BSIs

2007

Harrington [81]

gel

Jan 2003-May 2007

Australia

Significant decrease in MRSA BSI

2008

Rupp [3]

gel

Aug 2001-Sep 2003

USA

No change in device-related infections/MDROs/CDI

2009

Al-Naami [82]

gel

Oct 2007-Juh 2008

Saudi Arabia

Decrease in surgical site infections

2010

Carboneau [83]

gel

Mar 2006-Feb 2007

USA

Non-significant decrease in nosocomial MRSA infections

2011

Yeung [84]a

gel

Jan 2007 -Oct 2007

Hong Kong

Significant decrease in HAIs

2011

Marra [85]

gel

Jul 2008-Dec 2009

Brazil

Significant decrease in device-related HAIs

2011

Garcia–Vazquez [86]

gel

Not stated

Spain

Significant decrease in HAIs

2012

Kirkland [87]

gel

Jan 2006-Nov 2009

USA

Significant decrease in HAIs

2012

Mestre [88]

gel

Mar 2007-Dec 2011

Spain

Significant decrease in healthcare-acquired MRSA

2013

Talbot [89]

gel

Jan 2007-Aug 2012

USA

Significant decrease in device-related infections

2013

Salama [90]

gel

Feb 2011 – Aug 2011

Kuwait

Significant decrease in HAIs

2013

Iacobelli [91]

gel

Jan 2007-Dec 2009

France

Significant decrease in MRSA infections and colonization

2014

Johnson [92]

gel

Apr 2006—Sep 2012

USA

Significant decrease in CLABSIs

2015

Fox [93]

gel

Dec 2009-Feb 2012

USA

Decrease in CLABSIs and CAUTIs

2015

Chun [94]

gel

Oct 2008-Jan 2009

South Korea

Significant decrease in MRSA acquisition and colonization pressure

2016

Shabot [95]

gel

Oct 2010-Dec 2014

USA

Significant decrease in ICU CLABSI and VAP

2018

Ragusa [96]

gel

2015–2016

Italy

Increase in CDI

2018

Al-Tawfiq [97]

gel

2014-Sep 2015

Saudi Arabia

Decreases in CDI, CLABSIs and CAUTIs

2018

De la Rosa-Zamboni [98]

gel

Jan 2013—Aug 2013

Mexico

Significant decrease in HAIs

2018

Lenz [99]

gel

Jun 2011-Apr 2012

Argentina

Significant decrease in CABSIs

2020

Ojanpera [100]

gel

2013–2018

Finland

Significant decrease in HAIs

2021

Banks [101]

gel

Jun 2017-Jul 2019

USA

Significant decrease in CDI

2021

Akkoc [102]

gel

Apr 2016—Aug 2016

Turkey

Significant decrease in HAIs, with non-significant decrease in device-related infections

2023

Ragonese [103]

gel

Nov 2017-Dec 2020

Italy

Significant decrease in HA-CRE colonization rate

2004

Swoboda [104]

foam

Jul 2000-Oct 2001

USA

Significant decrease in MRSA or VRE infection/colonization; non-significant decrease in overall HAIs

2010

Helms [105]

foam + gel

Aug 2007-Jun 2008

USA

Non-significant decrease in HAIs

2010

Knight [106]

foam

Jan 2001-Jun 2008

USA

Significant decrease in HO-CDI

2013

Raschka [107]

gel—> foam

2007–2011

Canada

Non-significant decrease in selected HAIs

2013

Schweon [108]

foam

May 2009-Feb 2011

USA

Significant decrease in lower respiratory infections;

Decrease in skin & soft tissue infections

2016

Sickbert-Bennett [109]

foam

Oct 2013-Feb 2015

USA

Significant decrease in HAIs

2016

Kelly [110]

foam

Jul 2012-Mar 2015

USA

Significant decrease in MRSA infections

2018

McCalla [111]

foam

Jan 2014-Sep 2017

USA

Significant decrease in CLABSIs and CAUTIs

2019

Boyce [112]

foam

Jun 2014-Jun 2018

USA

Decrease in non-CDI; increase in CDI

2020

Leis [113]a

foam

Jun 2017-Dec 2018

Canada

Non-significant decrease in MRSA colonization/infection; not HA-BSIs or CDI

2020

Knepper [114]

foam

July 2016-Dec 2017

USA

Significant decrease in CDI. No change in other HAIs

2023

Barrett [115]

foam

Feb 2018-Sep 2021

USA

Significant decrease in MRSA infections

  1. aHealthcare Outcome refers to reduced transmission of healthcare pathogens and/or healthcare-associated infections. HAIs Healthcare-associated infections, MRSA Methicillin-resistant S. aureus, BSIs Bloodstream infections, NICU Neonatal intensive care unit, CLABSIs Central line-associated bloodstream infections, HA-MRSA Healthcare-associated MRSA, VRE Vancomycin-resistant enterococci, SIRs Standardized infection ratios, MDROs Multidrug-resistant organisms, ICU Intensive care unit, CRAB Carbapenem-resistant Acinetobacter baumannii, HABSIs Healthcare-associated BSIs, CAUTIs Catheter-associated urinary tract infections, CDI Clostridioides difficile infection, VAP Ventilator-associated pneumonia, CABSIs Catheter-associated BSIs, HA-CRE Healthcare-associated carbapenem-resistant Enterobacteriaceae, HO-CDI Hospital-onset CDI