Table 1 Baseline comparison of participants according to procedure
Characteristics | Standard procedure N = 25 | Extended procedure with tooth brushing N = 31 | p value |
|---|---|---|---|
Age [years] | 67 (56–73.5) | 67 (62–79) | NS |
Female [n (%)] | 10 (40.0%) | 14 (45.2%) | NS |
WHO ordinal scale, on admission to an ICU [43] | 7 (6–9) | 6 (5–9) | NS |
Baseline BOAS, sum score | 11 (9.5–12.5) | 12 (11.25–14.8) | 0.032 |
Baseline BOAS category | NS | ||
1–10 | 9 (36.0%) | 4 (16.7%) | |
11–20 | 16 (64.0%) | 20 (83.3%) | |
Baseline BOAS, teeth | 3 (2–3) | 3 (2–4) | NS |
In-hospital pharmacotherapy before intubation [n (%)] | |||
Steroid therapy | 19 (76.0%) | 21 (77.8%) | NS |
Antibiotic | 19 (76.0%) | 14 (51.9%) | NS |
DOT before intubation [days] | 7 (2.8–13.3) | 7 (3–15) | NS |
Baseline number of genera, all sites | 4 (3–5) | 5 (4–6) | 0.031 |
Baseline number of species, all sites | 5 (4–6) | 7 (5–9) | 0.006 |
Baseline number of patients with selected genera/species | |||
Acinetobacter baumannii | 31.0% | 16.1% | NS |
Enterococcus faecalis | 52.0% | 29.0% | NS |
Escherichia coli | 16.0% | 19.4% | NS |
Klebsiella pneumoniae | 28.0% | 12.9% | NS |
Lactobacillus spp. | 56.0% | 58.1% | NS |
Streptococcus spp. | 76.0% | 83.9% | NS |
Baseline CFU/ml from oral samples | |||
All bacterial strains | 4.0E + 5 (5.0E + 4–1.5E + 6) | 4.0E + 5 (1.0E + 5–1.4E + 6) | NS |
All G + strains | 5.0E + 5 (1.5E + 5–1.5E + 6) | 5.0E + 5 (1.5E + 5–1.5E + 6) | NS |
All G- strains | 2.3E + 4 (2.8E + 3–2.3E + 5) | 2.0E + 5 (2.0E + 4–8.0E + 5) | 0.021 |
Streptococcus spp. | 7.0E + 5 (1.8E + 5–2.2E + 6) | 4.0E + 5 (1.5E + 5–1.5E + 6) | NS |
Lactobacillus spp. | 1.0E + 6 (2.0E + 5–2.0E + 6) | 9.0E + 5 (2.0E + 5–2.0E + 6) | NS |
Klebsiella pneumoniae | 3.0E + 4 (3.0E + 2–5.0E + 4) | 1.5E + 4 (1.6E + 3–1.4E + 5) | NS |
Acinetobacter baumannii | 1.3E + 4 (2.3E + 3–1.9E + 4) | 1.0E + 4 (1.6E + 3–1.1E + 5) | NS |
Enterococcus faecalis | 3.0E + 5 (7.0E + 4–1.0E + 6) | 5.0E + 5 (2.1E + 4–5.4E + 6) | NS |