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Table 5 Variables associated with initial treatment failure in children

From: Success rates of MRSA decolonization and factors associated with failure

 

Total

(n = 35)

Initial treatment success (n = 15)

Initial treatment failure (n = 20)

P-value univariable

Age, median

9

7

10.5

Not applicable

Gender, n (%)

Male

Female

14

21

6 (42.9)

9 (42.9)

8 (57.1)

12 (57.1)

1

Adopted and cleft lip/palate, n (%)

No

Yes

31

4

12 (38.7)

3 (75.0)

19 (61.3)

1 (25.0)

Not applicable

Pets

No

Yes

25

10

12 (48.0)

3 (30.0)

13 (52.0)

7 (70.0)

0.46

MRSA source, n (%)

Unknown a

3

2 (66.7)

1 (33.3)

Not applicable

Hospital-acquired

5

3 (60.0)

2 (40.0)

Livestock-associated

2

2 (100.0)

0 (0.0)

Community-acquired

10

4 (40.0)

6 (60.0)

Living in refugee centre

15

4 (26.7)

11 (73.3)

Comorbidity, n (%) b

No

Yes

23

12

11 (47.8)

4 (33.3)

12 (52.2)

8 (66.7)

0.49

Chronic pulmonary disease

2

1 (50.0)

1 (50.0)

Not applicable

Skin disease

4

2 (50.0)

2 (50.0)

Not applicable

Renal disease c

4

1 (25.0)

3 (75.0)

Not applicable

Devices d

6

1 (16.7)

5 (83.3)

Not applicable

AB use in the past 3 months, n (%) e

No

Yes

32

3

14 (43.8)

1 (33.3)

18 (56.3)

2 (66.7)

Not applicable

Hospital admission in the Netherlands in the past year, n (%) e

No

Yes

30

5

13 (43.3)

2 (40.0)

17 (56.7)

3 (60.0)

1

Skin lesions, n (%)

No

Yes

28

7

10 (35.7)

5 (71.4)

18 (64.3)

2 (28.6)

0.11

Travel abroad in the past year, n (%) e, f

No

Yes

20

11

9 (45.0)

6 (40.0)

11 (55.0)

9 (60.0)

1

Type of MRSA carriage, n (%)

Uncomplicated carriage

4

2 (50.0)

2 (50.0)

Not applicable

Complicated carriage

29

12 (41.4)

17 (58.6)

Infection & Complicated carriage

2

1 (50.0)

1 (50.0)

Location of MRSA carriage, n (%)

Nasal carriage

18

9 (50.0)

9 (50.0)

0.50

Non-nasal carriage

17

6 (35.3)

11 (64.7)

0.50

Throat carriage

27

10 (37.0)

17 (63.0)

0.06

Perineal carriage

10

7 (70.0)

3 (30.0)

0.25

Other sites

5

1 (20.0)

4 (80.0)

0.67

PVL positivity, n (%)

No

Yes

30

5

14 (46.7)

1 (20.0)

16 (53.3)

4 (80.0)

0.29

  1. a Known risk factors are: previous MRSA carriage, contact with livestock, contact with MRSA positive person, hospital admission outside the Netherlands
  2. b The comorbidities mentioned below were merged together to get a larger sample size
  3. c Solid organ transplant (SOT) or dialysis
  4. d Tubing, catheters, probes, cannulas etc.
  5. e Measured counting from first visit infectious diseases consult
  6. f Travelling either to Asia, Africa, Central America or South America